Phenotypes Associated with This Genotype

Genotype
MGI:4354410

• Allelic Composition: Prkdc^tm1Gcl/Prkdc^tm1Gcl
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small Peyer's patches ( J:53765 )

• reduced or absent

absent Peyer's patches ( J:53765 )

• reduced or absent

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:53765 )

• absent

arrested B cell differentiation ( J:53765 )

abnormal T cell receptor beta chain V(D)J recombination ( J:53765 )

• reduced in quantity and variety

abnormal T cell receptor delta chain V(D)J recombination ( J:53765 )

• increased

absent mature B cells ( J:53765 )

abnormal spleen morphology ( J:53765 )

• spleens lack lymphocytes

small spleen ( J:53765 )

• 5- to 10-fold

abnormal lymph node morphology ( J:53765 )

• lymph nodes lack lymphocytes

small lymph nodes ( J:53765 )

• 5- to 10-fold

neoplasm

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

preneoplasia ( J:53765 )

• from 6 weeks to 6 months, mice exhibit preneoplastic lesions in the intestines unlike wild-type mice

cellular

increased cellular sensitivity to gamma-irradiation induced cell death ( J:53765 )

• survive of fibroblasts exposed to gamma radiation is reduced 100-fold compared to similarly treated wild-type cells

digestive/alimentary system

small Peyer's patches ( J:53765 )

• reduced or absent

absent Peyer's patches ( J:53765 )

• reduced or absent

abnormal large intestine crypts of Lieberkuhn morphology ( J:53765 )

• 3 of 21 mice exhibit aberrant crypt foci unlike in wild-type mice

abnormal colon morphology ( J:53765 )

• colonic glands exhibit increased cellularity compared to in wild-type mice

intestine polyps ( J:53765 )

• between 1 and 6 months, mice exhibit inflammatory polyps unlike wild-type mice

• 15 of 21 mice exhibit hypeplastic polypoid lesions with mild to moderate to severe (in 8 of 21 cases) epithelial cell dysplasia and suggestion of lamina propria invasion in severe cases

hematopoietic system

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:53765 )

• absent

arrested B cell differentiation ( J:53765 )

abnormal T cell receptor beta chain V(D)J recombination ( J:53765 )

• reduced in quantity and variety

abnormal T cell receptor delta chain V(D)J recombination ( J:53765 )

• increased

absent mature B cells ( J:53765 )

abnormal spleen morphology ( J:53765 )

• spleens lack lymphocytes

small spleen ( J:53765 )

• 5- to 10-fold

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:53765 )

• 3 of 21 mice exhibit aberrant crypt foci unlike in wild-type mice

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

homeostasis/metabolism

increased cellular sensitivity to gamma-irradiation induced cell death ( J:53765 )

• survive of fibroblasts exposed to gamma radiation is reduced 100-fold compared to similarly treated wild-type cells