Phenotypes Associated with This Genotype

Genotype
MGI:4354508

• Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn
• Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:76974 )

• calcium flux in B cells responds more quickly to B cell receptor binding

mortality/aging

premature death ( J:76975 )

• reduced life expectancy

• 9 of 43 mice die between 7 and 15 months of age

immune system

abnormal mature B cell morphology ( J:76974 )

• spleens are depleted of IgM^hi, IgD^hi B cells

• ncreased numbers of IgM^lo, IgD^hi B cells in the spleen

increased B-1 B cell number ( J:76974 )

• B1 cell population in the peritoneum is doubled

abnormal immune system physiology ( J:76974 )

abnormal B cell activation ( J:76974 )

• elevated activation of B cells in un-immunized mice

abnormal B cell calcium ion homeostasis ( J:76974 )

• calcium flux in B cells responds more quickly to B cell receptor binding

abnormal immunoglobulin level ( J:76974 )

• augmented response to T-cell dependent antigens

increased IgG level ( J:76975 )

• 50% of mice show elevated levels of multiple IgG subclasses

• by 18 months, 70% of mice have shown high titers of anti-DNA IgG (also 30% of heterozygotes at 12 months)

increased IgG2a level ( J:76975 )

• in 80% of autoimmune mice

increased IgM level ( J:76974 )

increased anti-double stranded DNA antibody level ( J:76974 , J:76975 )

• elevated by 5 months (J:76974)

• high titers particularly after 8 months (J:76975)

hematopoietic system

abnormal mature B cell morphology ( J:76974 )

• spleens are depleted of IgM^hi, IgD^hi B cells

• ncreased numbers of IgM^lo, IgD^hi B cells in the spleen

increased B-1 B cell number ( J:76974 )

• B1 cell population in the peritoneum is doubled

abnormal B cell activation ( J:76974 )

• elevated activation of B cells in un-immunized mice

abnormal B cell calcium ion homeostasis ( J:76974 )

• calcium flux in B cells responds more quickly to B cell receptor binding

abnormal immunoglobulin level ( J:76974 )

• augmented response to T-cell dependent antigens

increased IgG level ( J:76975 )

• 50% of mice show elevated levels of multiple IgG subclasses

• by 18 months, 70% of mice have shown high titers of anti-DNA IgG (also 30% of heterozygotes at 12 months)

increased IgG2a level ( J:76975 )

• in 80% of autoimmune mice

increased IgM level ( J:76974 )