About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4354597
cx19
Allelic
Composition
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (28 available); any H2 mutation (282 available)
Itktm1Ljb mutation (0 available); any Itk mutation (49 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery

hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/02/2024
MGI 6.13
The Jackson Laboratory