immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
|
• there are almost no mature transgenic CD4 T cells in the periphery
|
hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
|
• there are almost no mature transgenic CD4 T cells in the periphery
|