Phenotypes for H2 Itk Tg(TcrAND)53Hed MGI:4354598 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?
Genetic Background	involves: C3H/HeJ * C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (282 available)
H2^k mutation (15 available); any H2 mutation (282 available)
Itk^tm1Ljb mutation (0 available); any Itk mutation (49 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

hematopoietic system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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