Phenotypes Associated with This Genotype

Genotype
MGI:4354649

• Allelic Composition: Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:151612 )

• time to loss of righting reflex following treatment with volatile isoflurane, halothane, or sevofluane is lengthened compared to in similarly treated wild-type mice

• however, mice exhibit normal time to loss of withdrawal reflex, duration of loss of righting reflex, and recovery time following anesthetic treatment

• time to loss of righting reflex following intraveanous treatment with pentobarbital is lengthened compared to in similarly treated wild-type mice

• however, response to intravenous ketamine treatment is normal