Phenotypes Associated with This Genotype

Genotype
MGI:4358064

• Allelic Composition: Myb^tm1Ssp/Myb^tm1Ssp
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal angiogenesis ( J:63424 )

• the area of vascular network in mutant para-aortic splanchnopleural explants grown on stromal cells is reduced compared to wild-type

hematopoietic system

abnormal definitive hematopoiesis ( J:63424 )

• mutant embryo para-aortic splanchnopleural explant cultures on stromal cells generate only a smaller number of hematopoietic cells compared to wild-type embryo explants

abnormal erythropoiesis ( J:63424 )

• mutant derived para-aortic splanchnopleural explant cultures on stromal cells contain no erythroid cells

abnormal hematopoietic stem cell morphology ( J:63424 )

• para-aortic splanchnopleural explant cultures on stromal cells contain a 100-fold fewer hematopoietic progenitor cells than wild-type explants