cardiovascular system
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• under anesthetized conditions
|
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• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
|
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• in response to phenylephrine with L-NAME
|
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• in response to phenylephrine
|
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• in response to acetycholine
|
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• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice
|
homeostasis/metabolism
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• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice
|
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• prior to injury
|
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• prior to injury
|
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• basal serum nitric oxide metabolites compared with wild-type mice
|
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• mice exhibits reduced vasodilation in response to acetylcholine and altered vascular tone in response to phenylephrine with or without L-NAME compared with wild-type mice
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immune system
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• prior to injury
|
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• prior to injury
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muscle
|
• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
|
|
• in response to phenylephrine with L-NAME
|
|
• in response to phenylephrine
|
|
• in response to acetycholine
|


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