nervous system
N |
• brain development and Purkinje cell maturation are normal
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• direction of plasticity at parallel fiber-Purkinje cell synapses is reversed compared to in wild-type mice
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• protocols designed to stimulate long term depression induce long term potentiation (LTP)
• however, treatment with KN93 restores normal LTP induction
• protocols designed to stimulate long term potentiation induce long term depression (LTD)
|
• protocols designed to stimulate long term potentiation induce long term depression (LTD)
• however, treatment with cyclosporin A restores normal LTD induction
• protocols designed to stimulate long term depression induce long term potentiation (LTP)
|
behavior/neurological
• on a rotarod and balance beam
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