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Phenotypes Associated with This Genotype
Genotype
MGI:4360519
Allelic
Composition
Hprt1tm1(CUX1)Anep/Hprt1+
Genetic
Background
FVB.129P2-Hprt1tm1(CUX1)Anep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CUX1)Anep mutation (0 available); any Hprt1 mutation (1279 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 5 weeks, ductal outgrowth is faster than in wild-type mice
• however, at 3 months mammary gland development is normal
• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs

neoplasm
• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs

integument
• at 5 weeks, ductal outgrowth is faster than in wild-type mice
• however, at 3 months mammary gland development is normal
• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory