endocrine/exocrine glands
• at 5 weeks, ductal outgrowth is faster than in wild-type mice
• however, at 3 months mammary gland development is normal
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• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs
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neoplasm
• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs
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integument
• at 5 weeks, ductal outgrowth is faster than in wild-type mice
• however, at 3 months mammary gland development is normal
|
• after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice
• 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice
• mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)
• 3 mice with primary solid carcinoma exhibit metastasis to the lungs
|