Phenotypes Associated with This Genotype

Genotype
MGI:4361681

• Allelic Composition: Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:117329 )

• myeoablated mice restored with wild-type hematopoietic stem cells exhibit increased lethality compared with similarly treated wild-type mice

hematopoietic system

abnormal blood cell morphology/development ( J:117329 )

• transmarrow migration of transplanted bone marrow hematopoietic stem cells is absent unlike in similarly treated wild-type mice

• myeoablated mice restored with wild-type hematopoietic stem cells exhibit increased lethality compared with similarly treated wild-type mice

• 3 months after engraftment fewer donor cells are present in the microenvironment compared to in similarly treated wild-type mice

increased bone marrow cell number ( J:117329 )

increased hematopoietic stem cell number ( J:117329 )

skeleton

increased bone mineral density ( J:81625 )

• at 16 weeks, the ratio of mineral to matrix is increased in the cortical center and area of cortical bone adjacent to the endosteum compared to in wild-type mice

abnormal bone mineralization ( J:81625 )

• crystallinity in the bones of younger mice is increased compared to in wild-type mice