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Phenotypes Associated with This Genotype
Genotype
MGI:4362053
Allelic
Composition
Rasgrf2tm1Esn/Rasgrf2tm1Esn
Genetic
Background
involves: 129S1/Sv * C57BL/10 * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf2tm1Esn mutation (0 available); any Rasgrf2 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells stimulated with anti-CD3 and anti-CD28 antibodies produce 50% less IL2 than similarly treated wild-type cells
• T cells stimulated with anti-CD3 or anti-CD3 and anti-CD28 antibodies produce 50% less TNF-alpha than similarly treated wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory