Phenotypes Associated with This Genotype

Genotype
MGI:4366772

• Allelic Composition: Trpm6^tm1.1Rws/Trpm6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153718 )

• day 60 mortality is 4.7% compared to 0% in wild-type mice whether fed a high magnesium diet or not

homeostasis/metabolism

decreased circulating magnesium level ( J:153718 )

• mice exhibit modestly lower magnesium serum levels than in wild-type mice

• however, renal and fecal excretion of magnesium is normal