Analysis Tools
nervous system
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• both heterozygotes and homozygotes show enlarged Schwann cell-axon networks in a small number of myelinated axons of peripheral nerves by 10-14 weeks of age
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• regeneration of sciatic nerves esperimentally crushed at 10-14 weeks of age is impaired, but to a lesser degree than in homozygotes
• wild-type sciatic nerve engraftment progresses poorly within the distal endogenous heterozygous nerves with regeneration of the tissue impaired where wild-type axons encounter homozygous or heterozygous host Schwann cells
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