Phenotypes Associated with This Genotype

Genotype
MGI:4410463

• Allelic Composition: Pacs2^{Gt(OST426086)Lex}/Pacs2^{Gt(OST426086)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:136536 )

• mice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type micemice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type mice

• however, anti-Fas antibody Jo2- or LPS/galactosamine-induced hepatic apoptosis is normal

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:136536 )

• mice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type micemice treated with a TRAIL expressing adenovirus exhibit decreased apoptosis in the spleen compared with similarly treated wild-type mice

• however, TRAIl-induced liver steatosis is normal