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Phenotypes Associated with This Genotype
Genotype
MGI:4412004
Allelic
Composition		 Tlr4lps-n/Tlr4lps-n
Genetic
Background		 C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-n mutation (0 available); any Tlr4 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:5557 )
N
• mice are responsive to LPS stimulation
increased spleen weight ( J:37271 )
• spleen weight elevated with dextran sodium sulfate treatment
decreased acute inflammation ( J:37271 )
• distinctly lower endotoxin levels after 7 days of dextran sodium sulfate treatment compared to C3H/HeJ mice carrying the Tlr4Lps-d allele

hematopoietic system
increased spleen weight ( J:37271 )
• spleen weight elevated with dextran sodium sulfate treatment

growth/size/body
increased spleen weight ( J:37271 )
• spleen weight elevated with dextran sodium sulfate treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory