Phenotypes Associated with This Genotype

Genotype
MGI:4412090

• Allelic Composition: Foxg1^tm1(tTA)Lai/Foxg1⁺; Tg(tetO-Gsx2,-EGFP)1Kc/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:154936 )

• mice exhibit abnormal brain morphology during embryogenesis that is severe after E15.5

• however, doxycycline-treated mice exhibit improved brain morphology

abnormal telencephalon development ( J:154936 )

• mice exhibit an increase in the expression of ventral telencephalic markers throughout the pallium compared with Tg(tetO-Gsx2,-EGFP)1Kcam mice

abnormal olfactory bulb morphology ( J:154936 )

abnormal lateral ganglionic eminence morphology ( J:154936 )

• after E13.5, mice exposed to doxycycline between E7 and E9 exhibit expansion of the dorsal lateral ganglionic eminence, as determined by marker expression, compared with Tg(tetO-Gsx2,-EGFP)1Kcam mice