Phenotypes for Gli3 Ihh MGI:4414676 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Ihh^tm1Amc/Ihh^tm1Amc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (81 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone marrow cavity morphology ( J:154905 )

• the marrow cavity does not develop unlike in wild-type mice

• however, hypertrophic chondrocytes are normal

abnormal perichondrium morphology ( J:154905 )

• at E18.5, mice fail to exhibit bone deposition in the perichondrium flanking the hypertrophic regions where the bone collar normally forms in the long bones in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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