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Phenotypes Associated with This Genotype
Genotype
MGI:4415152
Allelic
Composition		 Grin2ctm1Nts/Grin2ctm1Nts
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2ctm1Nts mutation (0 available); any Grin2c mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:34597 )
• the non-NMDA component of the synaptic current was reduced in cerebellar granule cells
abnormal NMDA-mediated synaptic currents ( J:34597 )
• markedly potentiated in amplitude, but abbreviated in duration, with no net difference in total charge
• disappearance of low-conductance NMDA receptor channels (<37 pS) normally expressed in granule cells during developmental maturation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory