Phenotypes Associated with This Genotype

Genotype
MGI:4415816

• Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:155398 )

• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice

abnormal circadian temperature homeostasis ( J:155398 )

• in female mice during the light phase

impaired febrile response ( J:155398 )

• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice

decreased prostaglandin level ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:155398 )

• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice

• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice

• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice

immune system

decreased susceptibility to endotoxin shock ( J:155398 )

• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice