Phenotypes Associated with This Genotype

Genotype
MGI:4417857

• Allelic Composition: Gata3^tm1Iho/Gata3^tm1Iho; Tg(DO11.10)10Dlo/0; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

small thymus ( J:86996 )

decreased double-positive T cell number ( J:86996 )

• 10-fold reduction

arrested T cell differentiation ( J:86996 )

• partial impairment in generation of double positive cells

• partial arrest at the double negative 3 (DN3) to double negative 4 (DN4) transition

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

• 10-fold reduction

decreased CD8-positive, alpha-beta T cell number ( J:86996 )

immune system

small thymus ( J:86996 )

decreased double-positive T cell number ( J:86996 )

• 10-fold reduction

arrested T cell differentiation ( J:86996 )

• partial impairment in generation of double positive cells

• partial arrest at the double negative 3 (DN3) to double negative 4 (DN4) transition

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

• 10-fold reduction

decreased CD8-positive, alpha-beta T cell number ( J:86996 )

endocrine/exocrine glands

small thymus ( J:86996 )