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Phenotypes Associated with This Genotype
Genotype
MGI:4417906
Allelic
Composition		 Csf3tm1Ard/Csf3tm1Ard
Junbtm3Wag/Junbtm3Wag
Tg(KRT5-cre)1Tak/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3tm1Ard mutation (2 available); any Csf3 mutation (18 available)
Junbtm3Wag mutation (1 available); any Junb mutation (20 available)
Tg(KRT5-cre)1Tak mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to systemic lupus erythematosus ( J:155575 )
• mice develop systemic lupus erythematosus associated phenotypes unlike wild-type mice

renal/urinary system
abnormal kidney morphology ( J:155575 )
• mice exhibit systemic lupus erythematosus associated kidney defects observed in Junbtm3Wag/Junbtm3Wag Tg(KRT5-cre)1Tak mice

integument
abnormal epidermal layer morphology ( J:155575 )
• mice exhibit a partial rescue of epidermis defects observed in Junbtm3Wag/Junbtm3Wag Tg(KRT5-cre)1Tak mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory