Phenotypes Associated with This Genotype

Genotype
MGI:4417974

• Allelic Composition: Hand2^tm1Cse/Hand2⁺; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155265 )

• embryos survive at the expected Mendelian ratio until 9.5 dpc, with viablility dropping until 12.5 dpc after which no viable embryos are recovered

cardiovascular system

abnormal cardiac outflow tract development ( J:155265 )

• at 12.5 dpc, surviving embryos show hypoplastic outflow tract

abnormal heart ventricle morphology ( J:155265 )

• at 10.5 dpc severely affected embryos exhibit only a single clearly defined ventricle

decreased heart right ventricle size ( J:155265 )

• at 12.5 dpc, surviving embryos show hypoplastic right ventricle