Analysis Tools
homeostasis/metabolism
|
• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice
• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice
|
|
• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice
(J:96901)
• anandamide-treated mice fail to exhibit phase I (decreased mean arterial blood pressure, cardiac contractility, and heart rate) and exhibit a reduced phase II pressor response compared with similarly treated wild-type mice
(J:105525)
• capsaicin-treatment mice fail to exhibit a anandamide-like phase I and II response as in similarly treated wild-type mice
(J:105525)
• however, the prolonged hypotensive response to anandamide-treatment is normal
(J:105525)
• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice
(J:128319)
• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice
(J:132936)
• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice
(J:132936)
|
nervous system
|
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice
|
|
• in response to hyperosmotic stimulation, supraoptic nucleus neurons fail to generate an increase in membrane conductance and depolarizing potentials unlike similarly treated wild-type cells
|
|
• impulse frequency of action potentials in colon sensory neurons at 45 degrees Celsius is lower than in similarly treated wild-type cells
• colon sensory neurons fail to exhibit a sustained-type current response to protons unlike similarly treated wild-type cells
• colon sensory neurons fail to exhibit a temperature sensitive response or 5-HT effect unlike similarly treated wild-type cells
|
|
• temperatures below 50 degrees Celsius generate few action potentials in colon sensory neurons unlike in similarly treated wild-type cells
|
|
• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice
• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice
|
cardiovascular system
|
• after ischemia and during reperfusion
|
|
• after ischemia and during reperfusion
|
|
• after ischemia and during reperfusion
|
|
• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice
• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice
|
growth/size/body
|
• mice fed a high fat diet and treated with capsaicin fail to exhibit a decrease in body weight compared with similarly treated wild-type mice
|
behavior/neurological
| N |
• mice exhibit normal tactile hypersensitivity and allodynia following spinal nerve ligation
(J:132700)
• mice exhibit normal water consumption and ethanol-induced conditioned taste aversion
(J:153529)
|
|
• mice exhibit greater preference for ethanol than wild type mice in a two-bottle test
|
|
• mice consume more ethanol than wild-type mice in a two-bottle test
|
|
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
• however, mice exhibit normal acute ethanol withdrawal severity
|
|
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
|
|
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
|
|
• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice
|
|
• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice
|
taste/olfaction
|
• at high concentrations, mice exhibit a less aversion to FeSO4 than wild-type mice
• mice exhibit less aversion to 10 mM CuSO4 than wild-type mice
• however, aversion to ZnSO4 is normal
|
integument
|
• mice exhibit delays in the onset of catagen and telogen compared with wild-type mice
• however, follicle cycling is normal once initiated
|
|
• at P19, mice exhibit a retardation in catagen compared with wild-type mice
|
|
• slightly retarded at P25
|
cellular
|
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice
|
