Analysis Tools
behavior/neurological
| N |
• mice exhibit normal general locomotion and pain threshold
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• mice exhibit less freezing after stress sensitization compared with wild-type mice
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• mice exhibit less conditioned freezing in response to a context compared with wild-type mice
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• mice exhibit less conditioned freezing in response to an auditory cue compared with wild-type mice
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• in a light-dark test, mice spend more time exploring the light compartment than wild-type mice
• in an elevated plus maze, mice spend more time in open arms and make more entries into open arms compared with wild-type mice
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renal/urinary system
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• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion
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• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary albumin excretion
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• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation
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• DOCA-salt-treated mice exhibit a greater glomerulosclerosis than similarly treated wild-type mice
• however, DEXA treatment reduces glomerulosclerosis
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• DOCA-salt-treated mice exhibit more severe renal tubular injury in the renal cortex and outer medulla than similarly treated wild-type mice
• however, DEXA treatment reduces renal tubule damage
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nervous system
| N |
• mice exhibit normal paired-pulse facilitation, auditory brainstem responses, and distortion-product otoacoustic emissions
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• following high frequency stimulation, long term potentiation is weaker than in similarly treated wild-type mice
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homeostasis/metabolism
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• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion
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• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary albumin excretion
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• DOCA-salt-treated mice exhibit increased renal damage compared with similarly treated wild-type mice
• however, DEXA treatment ameliorates renal damage
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immune system
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• DOCA-salt-treated mice exhibit increased MCP-1 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
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• DOCA-salt-treated mice exhibit increased IL6 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
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• DOCA-salt-treated mice exhibit increased TNFalpha protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
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• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation
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