Analysis Tools
mortality/aging
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• 1 week after birth, few mice are still alive
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nervous system
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
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growth/size/body
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• surviving mice are smaller than wild-type mice
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cellular
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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