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Phenotypes Associated with This Genotype
Genotype
MGI:4418308
Allelic
Composition
Phox2btm2Jbr/Phox2b+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm2Jbr mutation (0 available); any Phox2b mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
• however, mice exhibit functional pre-Botzinger complex


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory