Phenotypes Associated with This Genotype

Genotype
MGI:4421419

• Allelic Composition: Cpt1b^tm1You/Cpt1b⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:131341 )

N • normal fasting blood glucose concentration

impaired adaptive thermogenesis ( J:131341 )

• 7% of heterozygous mice (n = 30) developed fatal hypothermia following a 3 h cold challenge, while none of the control mice (n = 30) were affected

• with a prolonged cold challenge (6 h), significantly more heterozygous mice developed fatal hypothermia (52% heterozygous mice vs. 21% control mice)

• with a prolonged cold challenge (6 h), an increased frequency of fatal hypothermia in females of both genotypes (67% female vs. 38% male heterozygous mice, and 33% female vs. 8% male control mice) is observed