Phenotypes for Apc Msh2 MGI:4429611 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Msh2^tm1Htr/Msh2^tm1Htr
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (157 available)
Msh2^tm1Htr mutation (1 available); any Msh2 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:45433 )

• survival is reduced 4-fold compared with Apc^Min heterozygotes

• all mice die within 5 months

neoplasm

increased gastrointestinal tumor incidence ( J:45433 )

• mice have an 8-fold increase in intestinal tumor load compared with Apc^Min heterozygotes

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:45433 )

• mice have an 8-fold increase in intestinal tumor load compared with Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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