Phenotypes Associated with This Genotype

Genotype
MGI:4430298

• Allelic Composition: Pura^tm1Kkh/Pura⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:85759 )

• occasional spontaneous seizures, usually following routine handling during cage changes

cellular

decreased cell proliferation ( J:85759 )

• cell proliferation in several tissues (cerebellum, hippocampus, thymus, spleen, lungs) is lower than in wild-type, but higher than in homozygotes

decreased DNA replication ( J:85759 )

• decrease in cells undergoing DNA replication in multiple organs, including the brain, thymus, spleen and lungs

growth/size/body

postnatal growth retardation ( J:85759 )

• delay in development

nervous system

seizures ( J:85759 )

• occasional spontaneous seizures, usually following routine handling during cage changes

homeostasis/metabolism

decreased DNA replication ( J:85759 )

• decrease in cells undergoing DNA replication in multiple organs, including the brain, thymus, spleen and lungs