Phenotypes Associated with This Genotype

Genotype
MGI:4430402

• Allelic Composition: Tg(Myh6-Gnaq)#Gwd/0; Tg(Myh6-tTA)55Rbns/0; Tg(tetO-Bnip3l)1Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145086 )

• all mice die between 6 and 8 weeks after birth

cardiovascular system

abnormal heart ventricle morphology ( J:145086 )

• mice exhibit ventricular remodeling as measured by the ratio of the ventricular radius to wall thickness unlike in wild-type mice

decreased cardiac muscle contractility ( J:145086 )

• drastically

muscle

decreased cardiac muscle contractility ( J:145086 )

• drastically

increased cardiomyocyte apoptosis ( J:145086 )

cellular

increased cardiomyocyte apoptosis ( J:145086 )