Phenotypes Associated with This Genotype

Genotype
MGI:4431391

• Allelic Composition: Foxg1^tm1M/Foxg1^tm1M
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neuronal precursor proliferation ( J:78115 )

• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

abnormal telencephalon morphology ( J:78115 )

• dorsal telencephalon is small

abnormal neocortex morphology ( J:78115 )

• neocortex has an irregular contour

embryo

abnormal neural tube mantle layer morphology ( J:78115 )

• thickness of the mantle zone in the dorsal telencephalon is increased due to accelerated neuronal differentiation

cellular

abnormal neuron differentiation ( J:78115 )

• accelerated neuronal differentiation in the neocortical neuroepithelium resulting in a marked increase in the thickness of the mantle

abnormal neuronal precursor proliferation ( J:78115 )

• neocortical progenitors in the dorsal telencephalon show a rapid increase in cell cycle length between E11.5 and E17.5 instead of the gradual increase in the length seen in wild-type mice