Phenotypes Associated with This Genotype

Genotype
MGI:4437076

• Allelic Composition: Chgb^tm1Ribo/Chgb^tm1Ribo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal chromaffin cell morphology ( J:157697 )

• basal catecholamine levels in chromaffin cells are lower than in wild-type cells

abnormal adrenal gland secretion ( J:157697 )

• evoked catecholamine secretions from chromaffin cell are decreased 33% compared to in wild-type mice

• exocytosis spikes are less than in wild-type cells

• L-DOPA-treated cells fail to uptake more catecholamines unlike similarly treated wild-type cells

• chromaffin cells exhibit a reduction in catecholamine secretion per quantal size of exocytosis compared with wild-type cells

• however, the frequency of exocytotic events is normal

homeostasis/metabolism

decreased adrenaline level ( J:157697 )

• adrenomedullary epinephrine levels are decreased 36% compared to in wild-type mice

nervous system

abnormal adrenal chromaffin cell morphology ( J:157697 )

• basal catecholamine levels in chromaffin cells are lower than in wild-type cells