Phenotypes Associated with This Genotype

Genotype
MGI:4440863

• Allelic Composition: Apc^Min/Apc⁺; Rab25^tm1Jrgo/Rab25^tm1Jrgo
• Genetic Background: B6.Cg-Rab25^tm1Jrgo Apc^Min

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rab25^tm1Jrgo/Rab25^tm1Jrgo Apc^Min/Apc⁺ mice exhibit increased intestinal adenoma formation compared to Apc^Min/Apc⁺ mice

neoplasm

increased intestinal adenoma incidence ( J:158733 )

• tubular adenomas in the intestine

• 4-fold increase in tumor number throughout the intestines compared with heterozygous Apc^min mice

increased colon adenoma incidence ( J:158733 )

• tubular adenomas in the colon

digestive/alimentary system

colon polyps ( J:158733 )

• 2-fold increase in colonic polyp number compared with heterozygous Apc^min mice

• increased polyp size

• more widely distributed polyps in the colon

increased intestinal adenoma incidence ( J:158733 )

• tubular adenomas in the intestine

• 4-fold increase in tumor number throughout the intestines compared with heterozygous Apc^min mice

increased colon adenoma incidence ( J:158733 )

• tubular adenomas in the colon

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:158733