About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4442856
Allelic
Composition		 Irf7m1Btlr/Irf7m1Btlr
Genetic
Background		 C57BL/6J-Irf7m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7m1Btlr mutation (1 available); any Irf7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:159358 )
• non-secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG
• reduced secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells in response to in vivo stimulation by resiquimod, a single-stranded (ss) RNA mimetic recognized by toll-like receptor 7 (TLR7)
decreased interferon-beta secretion ( J:159358 )
• non-secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG
• reduced secretion of type I interferons (IFN-alpha/IFN-beta) by plasmacytoid dendritic cells in response to in vivo stimulation by resiquimod, a single-stranded (ss) RNA mimetic recognized by toll-like receptor 7 (TLR7)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory