Phenotypes Associated with This Genotype

Genotype
MGI:4442863

• Allelic Composition: Irf7^m1Btlr/Irf7⁺
• Genetic Background: C57BL/6J-Irf7^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-alpha secretion ( J:159358 )

• reduced secretion of type I interferons (IFNalpha/IFNbeta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by resiquimod, a ss-RNA mimetic recognized by toll-like receptor 7 (TLR7)

• in contrast to the attenuated response of mice homozygous for this mutation, heterozygous mutant mice exhibit normal secretion of type I interferons by plasmacytoid dendritic cells in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG

decreased interferon-beta secretion ( J:159358 )

• reduced secretion of type I interferons (IFNalpha/IFNbeta) by plasmacytoid dendritic cells (pDCs) in response to in vivo stimulation by resiquimod, a ss-RNA mimetic recognized by toll-like receptor 7 (TLR7)

• in contrast to the attenuated response of mice homozygous for this mutation, heterozygous mutant mice exhibit normal secretion of type I interferons by plasmacytoid dendritic cells in response to in vivo stimulation by the toll-like receptor 9 (TLR9) ligand, CpG