Analysis Tools
mortality/aging
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• mice exhibiting zygotic cre expression die within a week of birth
• however, remaining mice survive at least 8 months
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nervous system
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• slightly at 2 months
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• at 2 months
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• striatum volume is reduced compared to in wild-type mice
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• striatal neurons are smaller than in wild-type mice with smaller cell bodies
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• dendritic complexity, number, length, and volume occupied in striatal neurons are reduced compared to in wild-type mice
• dendritic spine densities and total number of spines of striatal neurons are decreased compared to in wild-type mice
• CA1 hippocampal neuron exhibit reduced apical dendrite complexity and reduced proportion of mushroom spines where as mice exhibit an increased in the number of thin spines compared to in wild-type mice
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• the optic nerve is hypomyelinated and axonal diameters are reduced compared to in wild-type mice
• however, mice exhibit normal optic nerve cross-sectional area and axon numbers
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behavior/neurological
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• light/dark exploration is impaired compared to in wild-type mice
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• at 8 weeks
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• mice exhibit bursts of hyperactivity followed by periods of inactivity that were longer than normal
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growth/size/body
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• at 8 weeks, male mice are slightly lighter than wild-type mice
• however, by 4 weeks male mice exhibit normal body weight
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• by 6 weeks and there after, female mice exhibit mild to severe obesity with a 43% increased in body weight compared with wild-type mice
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vision/eye
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• the optic nerve is hypomyelinated and axonal diameters are reduced compared to in wild-type mice
• however, mice exhibit normal optic nerve cross-sectional area and axon numbers
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