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Phenotypes Associated with This Genotype
Genotype
MGI:4455043
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Runx2-icre)1Jtuc/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Runx2-icre)1Jtuc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• males exhibit a slight increase in crown-rump length compared to controls at 10 weeks

skeleton
N
• bone resorption is slightly decreased in both mutants and controls while osteoclast numbers are not affected
• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression
• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts
• in response to two weeks of treatment with the Nr3c1 agonist prednisolone, mutants do not display reduced bone mineral density in vertebral bones in contrast to treated controls
• mice show modest but highly significant decrease in bone density in calcified vertebral sections compared to controls at 3 months
• trabecular numbers are decreased but trabecular thickness is unaltered resulting in increased trabecular spacing
• osteoblast numbers, osteoblast surface, osteocytes, and osteoclast parameters are not significantly changed compared to controls
• bone formation in vertebrae is not inhibited whereas treated controls show near complete inhibition of bone formation with prednisolone treatment; osteoblastogenesis (numbers of colony forming units of osteoblasts) is not impaired as seen in controls with prednisolone treatment

cellular
• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression
• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory