Analysis Tools
skeleton
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• relative to wild-type, mice do not display differences in cartilage or calcified tissue; mice show similar bone mineral densities as wild-type and have no gross alterations in growth plate dimension or amount of calcified bone
• osteoblast differentiation is unaffected by this mutation
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• unlike wild-type cells, differentiation is not repressed by dexamethasone
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type
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cellular
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• unlike wild-type cells, differentiation is not repressed by dexamethasone
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type
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