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Phenotypes Associated with This Genotype
Genotype
MGI:4455055
Allelic
Composition
Nr3c1tm2.1Gsc/Nr3c1tm2.1Gsc
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2.1Gsc mutation (1 available); any Nr3c1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• relative to wild-type, mice do not display differences in cartilage or calcified tissue; mice show similar bone mineral densities as wild-type and have no gross alterations in growth plate dimension or amount of calcified bone
• osteoblast differentiation is unaffected by this mutation
• unlike wild-type cells, differentiation is not repressed by dexamethasone
• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type

cellular
• unlike wild-type cells, differentiation is not repressed by dexamethasone
• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory