Phenotypes Associated with This Genotype

Genotype
MGI:4456145

• Allelic Composition: Chgb^tm1Ribo/Chgb^tm1Ribo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal endocrine pancreas physiology ( J:157614 )

• decreased hormone secretion from islets of langerhans in vitro

• granule number and morphology of beta cells are unchanged

decreased insulin secretion ( J:157614 )

• in response to the glucose challenge, the peak in plasma insulin was decreased compared to wild type control

homeostasis/metabolism

decreased insulin secretion ( J:157614 )

• in response to the glucose challenge, the peak in plasma insulin was decreased compared to wild type control

impaired glucose tolerance ( J:157614 )

• plasma glucose level in response to i.p. glucose injection was higher than wild type control

• however, insulin sensitivity was not affected