Phenotypes Associated with This Genotype

Genotype
MGI:4456248

• Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge
• Genetic Background: involves: 129S/SvEv * DBA * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

proportional dwarf ( J:66913 )

postnatal growth retardation ( J:66913 )

• weight at birth and P10 is normal, however after 2 weeks post birth, mice are growth retarded

homeostasis/metabolism

increased circulating growth hormone level ( J:66913 )

skeleton

abnormal long bone epiphyseal plate proliferative zone ( J:66913 )

• proliferative zone of chondrocytes is shorter at p22 and p30

• chondrocyte proliferation in the proliferative zone is 63% of wild-type

abnormal long bone hypertrophic chondrocyte zone ( J:66913 )

• reduction in the rate of production and maturation of hypertrophic zone chondrocytes

decreased width of hypertrophic chondrocyte zone ( J:66913 )

• hypertrophic zones of chondrocytes are shorter at p22 and p30

abnormal trabecular bone morphology ( J:66913 )

• reduction in the height of the primary spongiosa

abnormal chondrocyte morphology ( J:66913 )

• average height of a hypertrophic chondrocyte is only about 70% of the controls

delayed endochondral bone ossification ( J:66913 )

• delay in development of diaphyseal and epiphyseal secondary ossification centers by more than 5 days