Phenotypes for Il1rl1 Il17rb MGI:4457620 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Il17rb^tm1Anjm/Il17rb^tm1Anjm Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rb^tm1Anjm mutation (0 available); any Il17rb mutation (42 available)
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

increased susceptibility to parasitic infection ( J:159464 )

• in response to infection with the helminth parasite N. brasiliensis, worm expulsion is severely impaired and mice possess significant worm burden at 20 days post infection

hematopoietic system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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