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Phenotypes Associated with This Genotype
Genotype
MGI:4459403
Allelic
Composition		 Tpbgtm1Plst/Tpbgtm1Plst
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpbgtm1Plst mutation (0 available); any Tpbg mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:160174 )
• median age of death is 49 days unlike wild-type mice

nervous system
hydrocephaly ( J:160174 )
• in 13% of mice

cellular
abnormal cell migration ( J:160174 )
• differentiated embryonic stem cells fail to respond to CXCL12 unlike similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory