Phenotypes Associated with This Genotype

Genotype
MGI:4461988

• Allelic Composition: Ccna1^tm1Djw/Ccna1^tm1Djw; Ccna2^tm1.1Pisc/Ccna2^tm1.1Pisc
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:155178 )

• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells

abnormal hematopoietic system physiology ( J:155178 )

• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells

cellular

abnormal cell cycle ( J:155178 )

• fibroblast cells treated with cre-expressing retroviruses exhibit an increase in the fraction o cells in the S and G2/M phase with a decrease in the G1 phase population compared with cells from wild-type mice

decreased cell proliferation ( J:155178 )

• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells