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Phenotypes Associated with This Genotype
Genotype
MGI:4461991
Allelic
Composition		 Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
Ccna2tm1.1Pisc mutation (0 available); any Ccna2 mutation (15 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:155178 )
• pIpC-treated mice die within 30 days

hematopoietic system
decreased common myeloid progenitor cell number ( J:155178 )
• in pIpC-treated mice (including CFU-G, CFU-M, CFU-GM, and CFU-GEMM)
anemia ( J:155178 )
• severe in pIpC-treated mice
decreased bone marrow cell number ( J:155178 )
• in pIpC-treated mice
decreased erythrocyte cell number ( J:155178 )
• in pIpC-treated mice
thrombocytopenia ( J:155178 )
• in pIpC-treated mice
decreased leukocyte cell number ( J:155178 )
• in pIpC-treated mice
decreased hematopoietic stem cell number ( J:155178 )
• pIpC-treated mice exhibit a reduction of common myeloid progenitors (CMP), granulocyte-macrophage progenitors (GMP), and megakaryocyte-erythroid progenitors (MEP) compared with similarly treated control mice

immune system
decreased leukocyte cell number ( J:155178 )
• in pIpC-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory