Phenotypes Associated with This Genotype

Genotype
MGI:4462850

• Allelic Composition: Ssbp2^tm1Lana/Ssbp2^tm1Lana
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:162035 )

• 50% of mice die by 68 weeks of age unlike wild-type mice

perinatal lethality, incomplete penetrance ( J:162035 )

• slightly fewer than expected live births are observed

neoplasm

increased adenoma incidence ( J:162035 )

• in the lung of one morbid mouse

increased lung adenoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice

increased lymphoma incidence ( J:162035 )

• in 6 of 13 morbid mice

• in 4 of 12 non-morbid mice

increased B cell derived lymphoma incidence ( J:162035 )

• in some mice

increased malignant tumor incidence ( J:162035 )

• 62% of moribund and 50% non-moribund mice develop full-blown malignancies between 60 and 80 weeks unlike wild-type mice

increased carcinoma incidence ( J:162035 )

• in 2 of 13 morbid mice (Hardian gland and lung)

increased jejunum adenocarcinoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice

increased squamous cell carcinoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice

increased sarcoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice

immune system

arteritis ( J:162035 )

• some mice exhibit polyarteritis unlike wild-type mice

increased pre-B cell number ( J:162035 )

• in the bone marrow at 6 weeks of age

decreased lymphocyte cell number ( J:162035 )

• in some mice with lymphomas

cardiovascular system

arteritis ( J:162035 )

• some mice exhibit polyarteritis unlike wild-type mice

renal/urinary system

abnormal kidney morphology ( J:162035 )

• some mice exhibit glomerular nephropathy unlike wild-type mice

skeleton

abnormal joint morphology ( J:162035 )

• some mice exhibit degenerative joint disease unlike wild-type mice

hematopoietic system

anemia ( J:162035 )

• in some mice

increased pre-B cell number ( J:162035 )

• in the bone marrow at 6 weeks of age

decreased lymphocyte cell number ( J:162035 )

• in some mice with lymphomas

pancytopenia ( J:162035 )

• in some mice with lymphomas

respiratory system

increased lung adenoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice

digestive/alimentary system

increased jejunum adenocarcinoma incidence ( J:162035 )

• in 1 of 12 non-morbid mice