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Phenotypes Associated with This Genotype
Genotype
MGI:4818273
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (43 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice

hematopoietic system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory