Analysis Tools
nervous system
|
• at asymmetric synapses, synaptic vesicles are more diffusely distributed and smaller than in wild-type mice
|
|
• fewer vesicles are docked at asymmetric synapses compared to in wild-type mice
• however, the number of docked vesicles at symmetric synapses is normal
|
|
• at P14, vesicle clustering in glutamatergic synapses is decreased in the CA3 compared to in wild-type mice
• CA3 pyramidal neurons cultured for 14 days have fewer glutamatergic vesicles associated with dendrites compared to in cultured wild-type neurons
• however, vesicle clustering in GABAergic synapses is normal
|
|
• the frequency of miniature excitatory postsynaptic currents (mEPSCs) is decreased compared to in wild-type hippocampal cultures
• however, the amplitude of mEPSCs is normal
|
