Phenotypes Associated with This Genotype

Genotype
MGI:4818490

• Allelic Composition: Sod2^{tm1(tetO-Sod2)Evbo}/Sod2^{tm1(tetO-Sod2)Evbo}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:162190 )

• mice die 1 to 3 weeks after birth

behavior/neurological

impaired balance ( J:162190 )

decreased locomotor activity ( J:162190 )

cellular

increased cardiomyocyte apoptosis ( J:162190 )

• in the superficial layers of the left ventricular wall

oxidative stress ( J:162190 )

• under normoxic conditions, primary fibroblasts exhibit increased production of reactive oxygen species compared with similarly treated wild-type cells

growth/size/body

decreased body size ( J:162190 )

muscle

increased cardiomyocyte apoptosis ( J:162190 )

• in the superficial layers of the left ventricular wall