Phenotypes Associated with This Genotype

Genotype
MGI:4818491

• Allelic Composition: Sod2^{tm1(tetO-Sod2)Evbo}/Sod2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:162190 )

myocardium necrosis ( J:162190 )

abnormal heart left ventricle morphology ( J:162190 )

• mice exhibit increased left ventricular internal diameter in systole compared with wild-type mice

cardiac fibrosis ( J:162190 )

decreased heart left ventricle muscle contractility ( J:162190 )

• left ventricular fractional area change, ejection fraction, and fractional shortening are decreased compared to in wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:162190 )

• mice are more susceptible to doxorubicin treatment with increased myocardial apoptosis, senescence, and degeneration compared with wild-type mice

muscle

increased myocardial fiber size ( J:162190 )

myocardium necrosis ( J:162190 )

decreased heart left ventricle muscle contractility ( J:162190 )

• left ventricular fractional area change, ejection fraction, and fractional shortening are decreased compared to in wild-type mice

increased cardiomyocyte apoptosis ( J:162190 )

• mice are more susceptible to doxorubicin treatment with increased myocardial apoptosis, senescence, and degeneration compared with wild-type mice

cellular

increased cardiomyocyte apoptosis ( J:162190 )

• mice are more susceptible to doxorubicin treatment with increased myocardial apoptosis, senescence, and degeneration compared with wild-type mice