Phenotypes Associated with This Genotype

Genotype
MGI:4818620

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)#Mam/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:162126 )

• tumors are less complex than in mice with one or two Chek1^tm2.1Sje alleles

increased tumor incidence ( J:162126 )

• mice exhibit increased tumor incidence compared to in mice with one or two Chek1^tm2.1Sje alleles

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age

increased lymphoma incidence ( J:162126 )

• in 4 of 10 mouse at 7 to 8 months of age

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age

integument

increased mammary gland tumor incidence ( J:162126 )

• in 5 of 10 mouse at 8 months of age

• in 1 of 10 mouse at 13 months of age